Chemistry: analytical and immunological testing – Hemoglobin – myoglobin – or occult blood
Patent
1987-04-10
1989-01-24
Marcus, Michael S.
Chemistry: analytical and immunological testing
Hemoglobin, myoglobin, or occult blood
G01N 3372
Patent
active
048001678
ABSTRACT:
A reagent system for determing the hemoglobin content of whole blood comprising an aqueous solution of polyvinylpyrrolidone of molecular weight from about 10,000 to about 360,000 at a pH greater than about 8.0 to denature hemoglobin in whole blood. A method is also provided wherein a blood sample is treted with an aqueous solution of polyvinylpyrrolidone of molecular weight from about 10,000 to about 360,000 at a basic pH sufficient to denature the hemoglobin present in the whole blood to form a stable product whereafter the absorbance of the stable product of the blood sample and polyvinylpyrrolidone of molecular weight from about 10,000 to about 360,000 polymer reagent system is measured at a wavelength of approximately 575 nm to determine the hemoglobin contentration.
REFERENCES:
patent: 4341527 (1982-07-01), Zander et al.
patent: 4673654 (1987-06-01), Talmage
Lyonnais et al., J. Lab. Clin, Med., (85)2, pp. 329-336 (1975).
Bailey Mark W.
Ulanday Myrna G.
Abbott Laboratories
Alfandary-Alexander Lyle
Brainard Thomas D.
Corneglio Donald L.
Katz Martin L.
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