Reagent and method for TBG assay

Details Reagent and method for TBG assay Reagent and method for TBG assay

1976-06-30

1977-06-28

Hunt, Brooks H.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424 12, 23230B, 232306, G01N 3300, A61K 3900

Patent

active

040326268

ABSTRACT:
The concentration of thyroxine binding globulin (TBG) in a fluid sample can be determined via radioassay technique with an immunochemical composite comprising anti-TBG antibodies immobilized on a water-insoluble carrier. The composite is incubated with the sample in a quantity sufficient to assure complexation of substantially all TBG in the sample to the antibodies of the composite. The quantity of TBG complexed is determined with radiolabeled thyroxine (T.sub.4) which complexes with at least a portion of the complexed TBG. By separating the labeled composite from the remaining labeled T.sub.4, and counting the bound (or unbound) T.sub.4, the concentration of TBG can be determined from a standard curve.

REFERENCES:
patent: 3933997 (1976-01-01), Hersh et al.
patent: 3960492 (1976-06-01), DiGiulio
patent: 3975511 (1976-08-01), Vann et al.

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