Reagent and method for determining activity of herpes protease

Details Reagent and method for determining activity of herpes protease Reagent and method for determining activity of herpes protease

1995-10-18

1998-01-13

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530324, 530325, 435 23, A61K 3802, C07K 500, C07K 700, C07K 1700

Patent

active

057081379

ABSTRACT:
A class of compounds is described for use as fluorogenic substrates for herpesvirus proteases and for use in an assay to identify inhibitors of herpesvirus proteases. ##STR1## wherein W is selected from glycine, 4-aminobutyric acid, 5-aminopentanoic acid, 6-aminocaproic acid and 7-aminoheptanoic acid; wherein Y is selected from EDANS, Abz, DANSYL, nicotinic acid, 4-guanidino-benzoic acid, N-methyl-Abz, 4-chloro-Abz, 5-chloro-Abz, 6-chloro-Abz, 3,5-dibromo-Abz, 6-amino-nicotinic acid, 2-amino-nicotinic acid, 2-chloronicotinic acid, niflumic acid and fluorogenic derivatives thereof; and wherein Z is selected from tryptophan, tyrosine, phenylalanine, p-nitrophenylalanine, m-nitrophenylalanine, DABSYL, DABCYL and halogenated derivatives thereof.

REFERENCES:
patent: 5011910 (1991-04-01), Marshall et al.
patent: 5506115 (1996-04-01), Toth et al.

Affiliated with

Also associated with

Rating

Reagent and method for determining activity of herpes protease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Reagent and method for determining activity of herpes protease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reagent and method for determining activity of herpes protease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-327590