Ready-to-use indomethacin-based eye lotion

Details Ready-to-use indomethacin-based eye lotion Ready-to-use indomethacin-based eye lotion

1996-09-04

1998-04-28

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424 7804, 424 7805, A61F 900, A61K 31715

Patent

active

057441545

ABSTRACT:
The present invention relates to a ready-to-use indomethacin eye lotion comprising, in aqueous solution:
indomethacin,
a .beta.- or .gamma.-cyclodextrin etherified with C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 hydroxyalkyl groups, the cyclodextrin being present in a molar ratio with respect to the indomethacin of at least 10/1, and the pH of the solution being from 4.0 to 6.0.

REFERENCES:
patent: 3459731 (1969-08-01), Gramera
patent: 4228160 (1980-10-01), Szeftli et al.
patent: 4727064 (1988-02-01), Pitha
patent: 4834985 (1989-05-01), Elger et al.
patent: 5227372 (1993-07-01), Folkman
patent: 5231089 (1993-07-01), Bodor
Chemical Abstracts, vol. 98, No. 26, 6/27/83, Columbus, Ohio abstract No. 221812, XP002002860 & JP-A-57 200 361 (Sumitomo Chemical Co. Ltd., JP) 12/8/82.

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