Reactive vesicle and functional substance-fixed vesicle

Details Reactive vesicle and functional substance-fixed vesicle Reactive vesicle and functional substance-fixed vesicle

1994-12-05

1996-07-30

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, A61K 9127

Patent

active

055409350

ABSTRACT:
A reactive vesicle comprising, as a vesicle-forming component, a reactive phospholipid derivative represented by the following general formula (1) and a functional substance-fixed vesicle prepared by reacting the reactive vesicle with a functional substance: ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) each represent an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average number of moles of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r each being an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkli metal atom.

REFERENCES:
patent: 5190822 (1993-03-01), Nishikawa et al.
patent: 5395619 (1995-03-01), Zalipsky
patent: 5399331 (1995-03-01), Loughrey
Journal of Liposome Research, vol. 2, No. 3, 1992, pp. 321-334, New York.
Database WPI, Section Ch, Week 9423, Derwent Publications Ltd.; AN 94-188081 & JP-A-6 126 152 (Nippon Oils & Fats Co. Ltd.) 10 May 1994.

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