Reactive neutralizing human anti-GP120 recombinant antibody, DNA

Details Reactive neutralizing human anti-GP120 recombinant antibody, DNA Reactive neutralizing human anti-GP120 recombinant antibody, DNA

1995-06-07

1998-12-22

Budens, Robert D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4241331, 4241351, 4241481, 435 696, 435 7021, 4351722, 4351723, 435328, 4353391, 4352523, 43525233, 5303873, 53038835, C07H 2104, A61K 3942, C07K 1610

Patent

active

058521860

ABSTRACT:
The present invention is directed to a recombinant human monoclonal antibody which binds to a discontinuous epitope on the HIV gp120 envelope glycoprotien, blocks the binding of gp120 to the CD4 receptor, and neutralizes a broad range of HIV isolates. The present invention also provides the primary nucleotide and deduced amino acid sequences of the rearranged heavy and light chains of the recombinant monoclonal antibody of the present invention, and a method of screening for antibodies which block binding of envelope glycoprotein to the CD4 receptor.

REFERENCES:
patent: 5215913 (1993-06-01), Posner
Barre-Sinoussi, et al., Science, 220:868-871 (1983).
Gallo, et al., Science 224:500-503 (1984).
Levy, et al., Science, 225:840-842 (1984).
Popovic, et al., Science, 224:497-500 (1984).
Sarngadharan, et al., Science 224:506-508 (1984).
Siegal, et al., New England Journal of Medicine, 305:1439-1444 (1981).
Zagury, et al., Science 231:850-853 (1986).
Patner, et al., Nature, 313:277-284 (1985).
Sanchez-Pescador, et al., Science, 227:484-492 (1985).
Muesing, et al., Nature, 313:450-457 (1985).
Wain-Hobson, et al., Cell, 40:9-17 (1985).
Sodroski, et al., Science, 231:1549-1553 (1986).
Arya et al., Science, 229:69-73 (1985).
Sodroski, et al., Nature, 321:412-417 (1986).
Feinberg, et al., Cell, 46:807-817 (1986).
Haseltine, Journal of Acquired Immune Deficiency Syndrome, 1:217-240 (1988).
Cohen, et al., Nature, 334:532-534 (1988).
Wang-Staal, et al., AIDS Res. and Human Retro Viruses, 3:33-39 (1987).
Guyader, et al., Nature, 326:662-669 (1987).
Chakrabarti, et al., Nature, 328:543-547 (1987).
Berger, et al., PNAS, 85:2357-2361 (1988).
Dalgleish, et al., Nature, 312:763-767 (1984).
Kaltzmann, et al., Nature, 312:767-768 (1984).
Fauci, et al., Ann. Int. Med., 100:92-99 (1984).
Haigwood, et al., Vaccines, 90:313-320 (1990).
Steimer, et al., Science, 254:105-108 (1991).
Rusche, et al., PNAS, 85:3198-3202 (1988).
Goudsmit, et al., PNAS, 85:4478-4482 (1988).
Palker, et al., PNAS, 85:1932-1936 (1988).
Kang, et al., PNAS, 88:6171-6175 (1991).
McKeating, et al., AIDS, 3:777-783 (1989).
Looney, et al., Science, 241:357-360 (1988).
Ho, et al., J. Virol. 61:2024-2028 (1987).
Nara, et al., J. Virol., 61:3173-3180 (1988).
Goudsmit, et al., Vaccine, 6:229-238 (1988).
McDougal, et al., J. Immunol., 137:2937-2944 (1986).
Ardman, et al., J. AIDS, 3:206-214 (1990).
Schnittman, et al., J. Immunol. 141:4181-4186 (1988).
Olshevsky, et al., J. Virol., 64:5701-5707 (1990).
Thali, et al., J. Virol., 65:6188-6193 (1991).
Posner, et al., J. Immunol., 146:4325-4332 (1991).
Marks, et al., J. Mol. Biol., 222:581-597 (1991).
McCafferty, et al., Nature, 348:552-554 (1990).
Winter, et al., Nature, 349:293-299 (1991).
Fahey, et al., Clin. Exp. Immunol., 88:1-5 (1992).
Morrison, et al., Proc. Natl. Acad. Sci. USA, 81:6851-6855 (1984).
Queen, et al., Proc. Natl. Acad. Sci. USA, 86:10029-10033 (1989).
Huston, et al., Proc. Natl. Acad. Sci. USA, 85:5879-5883 (1988).

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