Reactive asymmetrical dicarboxylic acid esters and reagents for

Details Reactive asymmetrical dicarboxylic acid esters and reagents for Reactive asymmetrical dicarboxylic acid esters and reagents for

1980-10-27

1984-03-13

Nucker, Christine M.

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

Producing labeled antigens

260112B, 536 61, 548475, A61K 4300, G01N 3356, C07G 700

Patent

active

044368283

ABSTRACT:
New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R.sub.1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R.sub.2 and R.sub.3, which may be the same or different, are alkoxy radicals containing up to 3 carbon atoms or together represent an oxygen atom, X is a cyanomethoxy, succinimide-N-oxy, N-methyl-pyridiniumoxy, 2,4-dinitrophenoxy, 2,4,5-trichlorophenoxy, pentachlorophenoxy, phenylthio, p-nitrophenoxy, p-nitrophenylthio, piperidyl-N-oxy, phthalimido-N-oxy or benztriazol-N-oxy radical and n is 2, 3, 4 or 5, are useful for the preparation of reagents for the investigation of cardiac glycosides (Digitalis glycosides).

REFERENCES:
patent: 3953431 (1976-04-01), Rutner et al.
patent: 3981982 (1976-09-01), Oslapas et al.
patent: 3997525 (1976-12-01), Guy
patent: 4115539 (1978-09-01), Eisenhardt, Jr. et al.
patent: 4133949 (1979-01-01), Batz et al.
patent: 4221725 (1980-09-01), Berixstein et al.
patent: 4282151 (1981-08-01), Batz et al.
Weiler et al., Clin. Chem., 25/1, 44-47, (1979).
Roeder et al., Chem. Abstracts, vol. 91, Abstract #153603c, (1979).

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