Reactive 1,3′-crosslinked carbocyanine

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S455000, C548S427000, C540S472000, C540S465000

Reexamination Certificate

active

07465810

ABSTRACT:
Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.

REFERENCES:
patent: 4147862 (1979-04-01), Hayami et al.
patent: 4314058 (1982-02-01), Hayami et al.
patent: 5439797 (1995-08-01), Tsien et al.
patent: 6074834 (2000-06-01), Slezak et al.
patent: 6926885 (2005-08-01), Licha et al.
Wikipedia encyclopedia under Macrocycle.
Examiner's serach report.
David E. Wolf, “Determination of the Sidedness of Carbocyanine Dye Labeling of Membranes,” Biochemistry, (1985), vol. 24, pp. 582-585.
Ping Chen, et al., “Structure and Solvent Effect on the Photostability of Indolenine Cyanine Dyes,” Elsevier Science Ltd., Dyes and Pigments, (1999), vol. 41, pp. 227-231.

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