Reactivation of interferon

Details Reactivation of interferon Reactivation of interferon

1975-04-03

1977-04-12

Gotts, Lewis

Drug, bio-affecting and body treating compositions

Lymphokine

260112R, A61K 4502

Patent

active

040176002

ABSTRACT:
An aqueous interferon solution wherein the interferon has lost at least part of its initial activity is reactivated by treatment with a combination of (a) an agent for disrupting non-covalent bonds, (b) an agent for reducing disulfide bridges, and (c) an anionic or cationic surface-active agent. A heat-treatment is preferably added. Agent (a) is urea or guanidine-hydrochloride and agent (b) is mercaptoethanol or ethanethiol.

REFERENCES:
patent: 3415804 (1968-12-01), Polson et al.

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