Reaction reagent for trifluoromethylation

Details Reaction reagent for trifluoromethylation Reaction reagent for trifluoromethylation

2011-07-19

2011-07-19

Anthony, Joseph D (Department: 1761)

Compositions

Compositions containing a single chemical reactant or plural...

Organic reactant

C252S182120, C252S182300, C252S182150, C252S183110, C252S183130, C252S186420, C252S186430

Reexamination Certificate

active

07981318

ABSTRACT:
Provided is a reaction reagent for trifluoromethylation with high general versatility and good efficiency.The reaction reagent for trifluoromethylation contains an iron compound, trifluoromethyl iodide, a sulfoxide and a peroxide, and may further contain an acid. The iron compound is, for example, iron(II) sulfate, ammonium iron(II) sulfate, iron(II) tetrafluoroborate, ferrocene, bis(η5-pentamethylcyclopentadienyl)iron or an iron powder; the sulfoxide is, for example, dimethyl sulfoxide; the peroxide is, for example, hydrogen peroxide or hydrogen peroxide-urea composite; and the acid is, for example, sulfuric acid, tetrafluoroboric acid or trifluoromethanesulfonic acid.

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