Rationally designed polysaccharide lyases derived from...

Details Rationally designed polysaccharide lyases derived from... Rationally designed polysaccharide lyases derived from...

2006-09-12

2006-09-12

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

07105334

ABSTRACT:
The invention relates to rationally designed polysaccharide lyases and uses thereof. In particular, the invention relates to modified chondroitinase B. The modified chondroitinase B enzymes of the invention are useful for a variety of purposes, including cleaving and sequencing polysaccharides such as glycosaminoglycans (GAGs) as well as removing polysaccharides from a solution. The invention also includes methods of inhibiting anticoagulant activity, inhibiting angiogenesis, treating cancer, and inhibiting maternal malarial infection.

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