Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Patent
1992-10-28
1996-08-27
Stone, Jacqueline M.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
424 91, 800 2, 935111, A61K 4900, C12N 1500, G01N 3700
Patent
active
055498841
ABSTRACT:
This invention provides a unique and surprisingly accurate animal model for human schizophrenia. The animals are brain damaged while prepubescent. The brain damage consists of a ventral hippocampus lesion induced by exposure of the hippocampus region to a neurotoxin. When the animal reaches puberty, abnormal behavior and a number of biological phenomena associated with schizophrenic symptoms emerge. These animals are useful for assaying pharmaceutical compounds for anti-schizophrenic activity.
REFERENCES:
R. L. Port et al. (1991) Brain Research Bulletin 26:993-996.
B. K. Lipska et al. (1992) Brain Research 585:1-6.
J. Feldon et al. (1992) J. Psychiatric Research 26(4):345-366.
A. B. Scheibel et al. (1993) 19(1):21-33.
L. E. Adler et al. (1991) Schizophrenia Bulletin 17(1):19-24.
Beauregard, M., et al., "Schizophrenia a Result of Early Damage to the Hippocampal Formation? A Behavioral Study in Primates," Society for Neuroscience Abstracts, vol. 18(2), p. 872 (1992).
Lipska, B. K., et al., "Postbubertal Emergence of Mesolimbic Dopaminergic Supersensitivity after Excitotoxic Lesions of Ventral Hippocampus in the Rat," Society for Neuroscience Abstracts, vol. 18(2), No. 472.1 (1992).
Jaskiw George E.
Lipska Barbara K.
Weinberger Daniel R.
Railey II Johnny F.
Stone Jacqueline M.
The United States of America as represented by the Secretary of
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