Rat glutathione synthetase gene

Details Rat glutathione synthetase gene Rat glutathione synthetase gene

1995-02-13

2000-10-03

Lau, Kawai

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435183, 43525411, 4353201, 536 232, C12N 121, C12N 900, C12N 1563, C07H 2104

Patent

active

061271659

ABSTRACT:
The present invention relates to recombinant rat kidney glutathione synthetase. This enzyme can be used to prepare glutathione analogs, and to raise antibodies against glutathione synthetase.
The present invention further relates to a DNA molecule encoding rat kidney glutathione synthetase. The DNA molecule is useful for detecting the presence of the glutathione synthetase gene in animals, and for modifying cell and mammal glutathione production. The DNA molecule can also be used to construct models for evaluation of potential therapies.

REFERENCES:
patent: 4668624 (1987-05-01), Roberts
patent: 4879370 (1989-11-01), Meister
Warner, B. et al. (1993) "Expression of human Mn SOD in Chinese hamster ovary cells confer protection from oxidant injury" Am. J. Phys. 264(6 Pt 1):L598-605, Jun. 1983.
Meister, A., 1985, Glutatione Synthetase from Rat Kidney, Methods in Enzymology, 113:393-399.
Moore et al., 1986, Enzymatic synthesis of novel glutathione analogs, Fed. Proc. Fed. Am. Soc. Exp. BIol. 45(6):1789.
Snoke, J.E. and Bloch, K., J. Biol. Chem. 199:414 (1952).
Snoke, J.E., "Isolation and Properties of Yeast Glutathione Synthetase," J. Biol. Chem. 213:813-824 (1955).
Meister, A. in The Enzynmes (Boyer, P.D., ed) 3rd Ed. vol. 10, pp. 671-697, Academic Press, N.Y. (1974).
Yan, N. and Meister, A., J. Biol. Chem. 265:1588-1593 (1990).
Huang, C.-S., Anderson, M.E., and Meister, a., J. Biol. Chem. 268(27):20578-20583 (1993).
Huang, C.-S. Moore, W., and Meister, A., Proc. Natl. Acad. Sci., U.S.A. 85:2464-2468 (1988)
Seelig, G.F., and Meister, A., Methods in Enzymology 113, Chapter 47, pp. 379-390 (1985).
Seelig, G.F., and Meister, A., J. Biol. Chem. 259:3534-3538 (1984).
Gushima, H., Miya. T., Murata, K., and Kimura, A., J. Appl. Biochem. 5:210-218 (1983).
Gushima, H., Yasuda, S., Soeda, E., Yokota, M., Kondo, M. and Kimura, A., Nucl. Acids Res. 12(24):9299-9307 (1984).
Mooz, E.D, and Meister, A., "Tripeptide (Glutathione) Synthetase. Purification, Properties, and Mechanism of Action," Biochemistry, 6(6):1722-1734 (1967).
Mutoh, N., Nakagawa, C.W., Ando, S., Tanabe, K., and Hayashi, Y., Cloning and Sequencing of the Gene Encoding the Large Subunit of Glutathione Synthetase of Schizosaccharomyces Pombe, Biochem. Biophys. Res. Comm. 181(1):430-436 (1991).
Hayashi, Y., Nakagawa, C.W. and Mutoh, N., Biochem. Cell Biol., 69:115-121 (1991).
Grill, E., Loffler, S., Winnacker, E-L. and Zenk, M.H., Proc. Natl. Acad. Sci. U.S.A., 86:6838-6842 (1989).
Habenicht, A., Hille, S., and Knochel, W., "Molecular cloning of the large subunit of glutathione synthetase from Xenopus laevis embryos," Biochem Biophys. Acta 1174:295-298 (1993).
Oppenheimer, L, Wellner, V., Griffith, O., and Meister, A. (1979) "Glutathione Synthetase Purification From Rat Kidney and Map of the Substrate Binding Sites," J. Biol. Chem., 254(12):5184-5190.
Moore, W.R. et al., "Increased capacity for glutathione synthesis enchances resistance to radiation in Escherichia coli:A possible model for mamalian cell protection," Proc. Natl. Acad. Sci, USA,86:1461-1464 (1989).
Murata, K., Kimura, A., and Yajima, N., "Glutathione Synthetase of Aspergillus niger Structural Properties of the Enzyme in Prokaryotes and Eukaryotes," Agri. Biol. Chem. 53(4):1145-1149 (1989).
Nakagawa, C.G., Mutoh, N., and Hayashi, Y., "Glutathione synthetase from the fission yeast. Purfication and its unique heteromeric subunit structure," Biochem. Cell Biol. 71:447-453 (1993).
Watanabe, K., Yamano, Y., Murata, K., and Kimyra, A., "Glutathione production by Escherichia coli cells with hybrid plasmid containing tandemly polymerized genes for glutatione synthetase," Appl Microbiol biotechnol 24:375-378 (1986).
Peters, J.M., Dalrymple, B.P., and Jorgensen, W.K., "Sequence of a Putative Glutatione Synthetase II Gene and Flanking Regions From Anaplasma Cenrrale," Biochemical and Biophysical Research Communications 182(3):1040-1046 (1992).

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