Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1994-06-17
1998-12-15
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG4, 800DIG5, 4351723, 424 92, 530324, 530352, 530839, C12N 500, C12N 1500, A61K 4900, A61K 3800
Patent
active
058499881
ABSTRACT:
Methods of generating a rat having A.beta. deposits in the brain of the rat by injecting an amount of human A68 protein sufficient to result in formation of the deposits and subsequently examining the rat for the formation of the deposits are disclosed. Rats characterized by the presence of A.beta. deposits similar to those found in individuals with Alzheimer's disease are also disclosed. Methods of screening test compositions for prophylactic or therapeutic activity by generating a rat having A.beta. deposits in its brain, treating the animal with the test composition and examining the animal for therapeutic or prophylactic effectiveness are also disclosed.
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Lee Virginia M.-Y.
Shin Ryong-Woon
Trojanowski John Q.
Crouch Deborah
Trustees of the University of Pennsylvania
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