Rasagiline formulations and processes for their preparation

Details Rasagiline formulations and processes for their preparation Rasagiline formulations and processes for their preparation

2006-12-05

2009-08-11

Davis, Brian J (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C564S308000

Reexamination Certificate

active

07572834

ABSTRACT:
The subject invention provides a pharmaceutical composition comprising N-propargyl-1(R)-aminoindan mesylate; a pharmaceutically acceptable carrier; and greater than 0.7 ppm but less than 30 ppm in total of a compound having the structure:and any salts of the compound.

REFERENCES:
patent: 5387612 (1995-02-01), Youdim et al.
patent: 5453446 (1995-09-01), Youdim et al.
patent: 5457133 (1995-10-01), Youdim et al.
patent: 5486541 (1996-01-01), Sterling et al.
patent: 5519061 (1996-05-01), Youdim et al.
patent: 5532415 (1996-07-01), Youdim et al.
patent: 5576353 (1996-11-01), Youdim et al.
patent: 5599991 (1997-02-01), Youdim et al.
patent: 5668181 (1997-09-01), Youdim et al.
patent: 5744500 (1998-04-01), Youdim et al.
patent: 5786390 (1998-07-01), Youdim et al.
patent: 5891923 (1999-04-01), Youdim et al.
patent: 6126968 (2000-10-01), Peskin et al.
patent: 6277886 (2001-08-01), Levy et al.
patent: 6316504 (2001-11-01), Youdim et al.
patent: 6462222 (2002-10-01), Chorev et al.
patent: 6630514 (2003-10-01), Youdim et al.
patent: 6635667 (2003-10-01), Thomas
patent: 6956060 (2005-10-01), Youdim et al.
patent: 7491847 (2009-02-01), Frenkel
patent: 2004/0010038 (2004-01-01), Blaugrund et al.
patent: 2004/0052843 (2004-03-01), Lerner et al.
patent: 2004/0127577 (2004-07-01), Blaugrund et al.
patent: 2005/0093830 (2005-05-01), Li et al.
patent: 2006/0018957 (2006-01-01), Lerner et al.
patent: 2006/0094783 (2006-05-01), Youdim et al.
patent: 2006/0188581 (2006-08-01), Peskin
patent: 2007/0100001 (2007-05-01), Youdim et al.
patent: 2007/0112217 (2007-05-01), Frenkel et al.
patent: 2007/0232700 (2007-10-01), Blaugrund et al.
patent: 0538134 (1993-04-01), None
patent: 0436492 (1994-06-01), None
patent: 9511016 (1995-04-01), None
patent: 9518617 (1995-07-01), None
patent: 9637199 (1996-11-01), None
patent: 9712583 (1997-04-01), None
patent: 9802152 (1998-01-01), None
patent: 03072055 (2003-09-01), None
patent: 2004045515 (2004-06-01), None
patent: 2006057912 (2004-11-01), None
patent: 2007098264 (2007-08-01), None
patent: 1 08019871 (2008-02-01), None
patent: 2008076315 (2008-06-01), None
patent: 2008131961 (2008-11-01), None
U.S. Appl. No. 11/791,684, filed May 24, 2007, Patashnik et al.
U.S. Appl. No. 12/002,082, filed Dec. 13, 2007, Frenkel and Koltai.
U.S. Appl. No. 12/002,076, filed Dec. 13, 2007, Frenkel and Koltai.
Scientific Discussion (EMEA 2005), http://www.emea.europa.eu/humandocs/PDFs/EPAR/Azilet/528970en6.pdf, published Mar. 17, 2005, especially p. 9.
Finberg et al. (1981) “Selective Irreversible Propargyl Derivative Inhibitors of Monoamine Oxidase (MAO) without the Cheese Effect”Chem. Abstracts94:202499.
Finberg and Youdim (1985) “Modification of Blood Pressure and Nictitating Membrane Response to Sympathetic Amines by Selective Monoamine Oxidase Inhibitors”Brit. J.Pharmac. 85(2):541-546.
Finberg et al. (1985) “Modification of Blood Pressure and Nictitating Membrane Response to Sympathetic Amides by Selective Monoamide Oxidase Inhibitors, Types A and B, in the Cat”Chem. Abstracts103:81618.
U.S. Appl. No. 11/595,726, filed Nov. 10, 2006, Youdim et al.
U.S. Appl. No. 11/600,561, filed Nov. 15, 2006, Frenkel et al.
Mendlewicz and M.B.H. Youdim (1983)Brit. J. Psychiat. 142:508-511.
Youdim MBH, et al., “Rasagiline (N-propargyl-1R(+)-aminoindan), a selective and potent inhibitor of mitochondrial monoamine oxidase B”,Br. J. Pharmacol., 2001,132:500-6.
Youdim et al. in Handbook of Experimental Pharmacology vol. 90/I (1988) Chapter 3, Trendlenburg and Weiner, eds.
Youdim et al. (1984)Progress in Medicinal Chemistry21:138-167.
U.S. Appl. No. 12/223,794, filed Aug. 7, 2008, Poewe et al.
U.S. Appl. No. 12/283,022, filed Sep. 8, 2008, Sterling et al.
U.S. Appl. No. 12/283,105, filed Sep. 8, 2008, Sterling et al.
U.S. Appl. No. 12/283,107, filed Sep. 8, 2008, Sterling et al.
U.S. Appl. No. 12/283,946, filed Sep. 16, 2008, Lendvai et al.
U.S. Appl. No. 12/231,601, filed Sep. 3, 2008, Oron et al.
Office Action issued Mar. 5, 2009 in the U.S. Appl. No. 12/283,022, including the reference cited therein, i.e., “Paquette, L. A. et al. ”1,5-Asymmetric Induction in Squarate Cascades Conformational Control of Helicity by Chiral Amino Substituents during Conrotatory Octatetraene Cyslization Prior to Elimination“, J. Org. Chem., 1998, 63, 2022-2030”.
Office Action issued Mar. 27, 2009 in the U.S. Appl. No. 12/283,105, including the reference cited therein, i.e., “Kirk-Othmer Encyclopedia of Chemical Technology (2005), John Willy & Sons, Inc., Vol. 18, entry: Pharmaceuticals, p. 33, no. 11”.
Office Action issued Mar. 24, 2009 in the U.S. Appl. No. 12/283,107.
“Paquette, L. A. et al. ”1,5-Asymmetric Induction in Squarate Cascades Conformational Control of Helicity by Chiral Amino Substituents during Conrotatory Octatetraene Cyslization Prior to Elimination“, J. Org. Chem., 1998, 63, 2022-2030”.
“Kirk-Othmer Encyclopedia of Chemical Technology (2005), John Willy & Sons, Inc., vol. 18, entry: Pharmaceuticals, p. 33, No. 11”.
Office Action issued May 26, 2009 in U.S. Appl. No. 12/283,107, including the references cited therein, particularly, “U.S. Patent No. 5,387,612, issued Feb. 2, 1995 to Youdim et al.”, “U.S. Patent No. 6,277,886, issued Aug. 21, 2001 to Levy et al.”, and “Merriam-Webster dictionary, online version, www.merriam-webster.com/dictionarv/carbon- I 3 .com”.

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