Ras protein

Details Ras protein Ras protein

1997-12-16

1999-08-31

Lau, Kawai

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 6, 4352523, 4353201, 514 12, 514 44, 530350, 536 235, C12P 2106, C07K 1447, C07H 2104, C12Q 168

Patent

active

059453060

ABSTRACT:
The invention provides two human Ras proteins, referred to collectively as "RAPR" and individually as "RAPR-1" and "RAPR-2", and polynucleotides which identify and encode RAPR. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of RAPR.

REFERENCES:
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Hariharan, I.K. et al. "Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho 1 in retinal cells causes a late developmental defect." The EMBO Journal (Jan. 1995), vol. 14, No. 2, pp. 292-302.
Database EMBL-est54/GenBank-est 106, Accession number AA103047, Marra et al., The Washington University-HHMI Mouse EST Project, Oct. 29, 1996.
Database EMBL-est54/GenBank-est 106, Accession No. CO4513, Tanaka et al., Genomics, vol. 35 , No. 1, pp. 231-235 , Jul. 24, 1996.
Database EMBL-est54/GenBank-est 106, Accession No. AA053742 , Hillier et al., The Washington University-Merck EST Project, Sep. 13, 1996.
Tavitian, Armand, "Proteines RAS et proteines apparentees", C.R. Seances Soc. Biol. Fil, 189:7-12, (1995), (Summary in English-Article in French).
Icard-Liepkalns , C. et al. , "An ADP-ribosylation-factor (ARF)-like protein involved in regulated secretion", Eur. J. Biochem., 246:388-393, (1997), (GI 2062132; GI 2062133).
Hall , A. et al., "Cellular responses regulated by rho-related small GTP-binding proteins", Philos. Trans. R. Soc. Lond. B (Biol.), 340:267-271, (1993).
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Icard-Liepkalns, C. et al., (Direct Submission), GenBank Sequence Database (Accession 2062133), National Center for Biotechnology Information, National Library of Medicince, Bethesda, Maryland, 20894, (1997) (GI 2062132; GI 2062133).
Icard-Liepkalns, C. et al., (Direct Submission), GenBank Sequence Database (Accession Y12708), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (1997) (GI 2062132; GI 2062133).
Murphy, C. et al., (Direct Submission), GenBank Sequence Database (Accession 1702943), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (1996) (GI 1702942; GI 1702943).
Murphy, C. et al., (Direct Submission), GenBank Sequence Database (Accession X84325), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (1996) (GI 1702942; GI 1702943).
Ren, M. et al., "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase", Proc. Natl. Acad. Sci. USA, 93:5151-5155, (1996).

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