Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-03-20
1999-09-21
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Vector, per se
514 2, 514 12, 530350, 536 235, 536 2431, C07H 2104, C12N 1563, C12N 1579, A61K 3817
Patent
active
059553545
ABSTRACT:
A novel protein which interacts with ras p21, has been identified. This protein, RGL, shares 69% amino acid homology with ral guanine nucleotide dissociation stimulator (ralGDS). ralGDS was also found to bind ras p21. The ras p21-interacting domain of RGL (RID) bound to ras p21 through the effector loop of ras p21. Polypeptide and polynucleotide compositions of the RGL protein are provided as well as methods for implementing the diagnostic and therapeutic uses of these compositions. The uses include isolating effector proteins of ras p21 and modulating ras activity.
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Demo Susan
Williams Lewis T.
Gucker Stephen
Hutzell Paula K.
The Regents of the University of California
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