Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-09-22
2000-02-08
Feisee, Lila
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 231, 536 2431, 4353201, 435325, 4352523, 4351723, C07H 2104, C12N 1512, C12N 1563
Patent
active
060227079
ABSTRACT:
The invention provides a human Ras-like protein (PRAS) and polynucleotides which identify and encode PRAS. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PRAS.
REFERENCES:
Hillier et al.: "Homo Sapiens cDNA Clone 837891" EMBL Sequence Database, Accession Number AA434363, Jun. 1, 1997, XP002098457.
Hillier et al.: "Homo Sapiens cDNA Clone 795958" EMBL Sequence Database, Accession Number AA461242, Jun. 13, 1997, XP002098458.
Tavitian, A, "Proteines RAS et proteines apparentees", C. R. Soc. Biol., 189:7-12 (1995). Publication in French, abstract only in English.
Drivas, G.T. et al., "Characterization of Four Novel ras-like Genes Expressed in a Human Teratocarcinoma Cell Line," Molecular and Cellular Biology, 10 (4) : 1793-1798 (1990) (GI 190881).
Lee, C.J. et al., "Rin, a Neuron-Specific and Calmodulin-Binding Small G-Protein, and Rit Define a Novel Subfamily of Ras Proteins," The Journal of Neuroscience, 16 (21) 6784-6794 (1996).
Drivas, G.T. et al., (GI 190881) GenBank Sequence Database (Accession Z68341), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (GI 190880).
Drivas, G.T. et al., (GI 190880) GenBank Sequence Database (Accession Z68341), National Center for Biotechnology Information: National Library Medicine, Bethesda, Maryland 20849 (GI 190881).
Ren, M., et al., "It its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase," Proc. Natl. Acad. Sci. USA, 93:5151-5155 (1996).
Corley Neil C.
Hillman Jennifer L.
Shah Purvi
Basi Nirmal S.
Feisee Lila
Incyte Pharmaceuticals Inc.
Sather Susan K.
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