Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1994-10-25
1996-07-02
Datlow, Philip I.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
540523, 540493, 540497, 540498, 540499, 540504, 540509, 540558, A61K 3155, C07D22316, C07D22318
Patent
active
055323596
ABSTRACT:
Benzodiazepine derivatives are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases for which inhibition of the ras farnesyl:protein transferase is indicated. Also disclosed are benzazepines of the following general formula (II) having similar utility as the aforementioned benzodiazepines: ##STR1##
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James, G. et al., "Benzodiazepine peptidomimetics: potent inhibitors of ras farnesylation in animal cells" Science 260:1937-1941 (1993).
Brown Michael S.
Crowley Craig W.
Goldstein Joseph L.
James Guy L.
Marsters, Jr. James C.
Board of Regents , The University of Texas System
Datlow Philip I.
Genentech Inc.
Winter Daryl B.
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