Rary-specific retinobenzoic acid derivatives

Details Rary-specific retinobenzoic acid derivatives Rary-specific retinobenzoic acid derivatives

1995-06-06

1997-04-29

Conrad, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514563, 560 28, 562455, C07C27106, C07C22928, A61K 3124, A61K 3119

Patent

active

056249578

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## wherein X is F, Cl, OH or CH.sub.3, Y is H or F, R.sub.1 -R.sub.6 are each independently hydrogen or C.sub.1 -C.sub.6 alkyl, n is an integer of 1 to 4 and R.sub.7 is hydrogen or a carboxyl-protecting group, and pharmaceutically acceptable salts thereof. The compounds of formula I selectively interact with the retinoic acid subtype RAR.gamma. and have been found to lack the liver toxicity associated with systemic administration of non-selective retinoids.

REFERENCES:
patent: 5128479 (1992-07-01), Janssen et al.
Multiplicity generates diversity in the retinoic acid signalling pathways, Mark Leid et al, Trends in Biochemical Sciences, 17:427-433, 1995.

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