Rapidly dissolving robust dosage form

Details Rapidly dissolving robust dosage form Rapidly dissolving robust dosage form

1998-04-09

2000-02-15

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 424468, 424469, 424470, 424484, 424488, 424489, 424490, 424435, 514777, 514951, 514960, A61K 914, A61K 918, A61K 920, A61K 922, A61K 926

Patent

active

060249811

ABSTRACT:
The invention is directed to a hard tablet that can be stored, packaged and processed in bulk. Yet the tablet dissolves rapidly in the mouth of the patient with a minimum of grit. The tablet is created from an active ingredient mixed into a matrix of a non-direct compression filler and a relatively high lubricant content.

REFERENCES:
patent: 3962417 (1976-06-01), Howell
patent: 4613497 (1986-09-01), Chavkin
patent: 4639368 (1987-01-01), Niazi et al.
patent: 4687662 (1987-08-01), Schobel
patent: 4753792 (1988-06-01), Aberg
patent: 4940588 (1990-07-01), Sparks et al.
patent: 5055306 (1991-10-01), Barry et al.
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patent: 5225197 (1993-07-01), Bolt et al.
patent: 5464632 (1995-11-01), Cousin et al.
patent: 5536526 (1996-07-01), Virtanen et al.
patent: 5607697 (1997-03-01), Alkire et al.
U.S. Pharmacopoeia No. 23, 1995, Chap. 1216, "Tablet Friability".

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