Rapidly disintegrable pharmaceutical composition

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S451000, C424S452000, C424S464000, C424S465000, C424S489000

Reexamination Certificate

active

06899899

ABSTRACT:
The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.

REFERENCES:
patent: 4404183 (1983-09-01), Kawata et al.
patent: 4673564 (1987-06-01), Kawata et al.
patent: 4946686 (1990-08-01), McClelland et al.
patent: 5091191 (1992-02-01), Oda et al.
patent: 5211957 (1993-05-01), Hagemann et al.
patent: 56-110612 (1981-09-01), None
patent: 59-48810 (1984-11-01), None
patent: 2-704 (1990-04-01), None
patent: 3-240729 (1991-10-01), None
patent: 08231403 (1996-09-01), None
patent: 3-240729 (2001-10-01), None
Burnier et al., “Pharmacokinetic and pharmacodynamic effects of YM087, a combined V1/V2 vasopressin receptor antagonist i normal subjects”, European Journal of Clinical Pharmacology, vol. 55, pp 633-637, 1999.*
Tanaka et al., Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, Mar. 24-28, MEDI-139, American Chemica Society, 1996.*
S. Radhofer-Welte, P. Dittrich: Determination of the novel non-steroidal anti-inflammatory drug Iornoxicam and its main metabolite in plasma and synovial fluid; Journal of Chromatography B, 707 (1998) pp. 151-159.
Junichi Jinno, et al; Dissolution of Ionizable Water-Insoluble Drugs: The Combined Effect of pH and Surfactant; Journal of Pharmaceutical Sciences, vol. 89, No. 2, Feb. 2000, pp. 268-274.
International Preliminary Examination Report.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Rapidly disintegrable pharmaceutical composition does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Rapidly disintegrable pharmaceutical composition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rapidly disintegrable pharmaceutical composition will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3402648

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.