Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
1999-06-10
2001-04-03
Krass, Frederick (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S568000, C514S849000, C514S853000
Reexamination Certificate
active
06211246
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to medicaments that contain a combination of an analgesic/anti-inflammatory acidic compound and a pharmacologically active amine. In a preferred embodiment the present invention is related to the combination of materials in a liquid dosage form.
BACKGROUND OF THE INVENTION
Products which combine multiple pharmaceutically active ingredients are available commercially throughout the world. Consumers purchase these medicaments because they relieve several symptoms at the same time. For example, ibuprofen and pseudoephedrine are sold in combination in solid forms, such as tablets, capsules, and powders for re-constitution. Ibuprofen is an effective analgesic/antipyretic agent, whereas pseudoephedrine is an effective decongestant. The combination of these two active ingredients is particularly effective for relieving sinus headache, and symptoms of cold and flu. Ibuprofen and pseudoephedrine combinations are disclosed in U.S. Pat. No. 4,552,899.
While these products are known to be effective, consumers who use them are seeking faster symptom relief. Consequently, there continues to be a long felt need to develop products which bring rapid relief to the consumer.
Attempts have been made to improve the rate of onset of activity of various drugs by increasing their rates of absorption into the bloodstream following oral administration. For example, PCT application WO98/38983 discloses a method of improving the absorption rate of the analgesic, paracetamol, by combining it with sodium bicarbonate in a tablet or capsule formulation in a specific weight ratio. Irwin et. al. [J. Pharm. Sci. 58(3), March 1969] demonstrated enhanced absorption of the quaternary ammonium compound, isopropamide, when it was administered in combination with a large molar excess of trichloroacetate in solution. Meyer and Manning [Pharm. Res. 15(2), 1998] discuss the use of hydrophobic ion pairing to enhance the bioavailablity of poorly lipid-soluble protein and peptide drugs.
It has now been found, unexpectedly, that the absorption rate of a pharmaceutically active amine (such as pseudoephedrine) is improved when the amine is formulated together with an acidic non-steroidal anti-inflammatory drug (such as ibuprofen) in a liquid medium.
SUMMARY OF THE INVENTION
The present invention provides a method for enhancing the absorption of a pharmacologically active amine which comprises providing a pharmaceutically effective dose of the amine, and an effective dose of a non-steroidal anti-inflammatory agent together in a liquid medium to provide enhanced bio-absorption of the amine.
REFERENCES:
patent: 4479956 (1984-10-01), Sunshine et al.
patent: 4486436 (1984-12-01), Sunshine et al.
patent: 4522826 (1985-06-01), Sunshine et al.
patent: 4552899 (1985-11-01), Sunshine et al.
patent: 4558051 (1985-12-01), Sunshine et al.
patent: 4567183 (1986-01-01), Sunshine et al.
patent: 4585783 (1986-04-01), Sunshine et al.
patent: 4587249 (1986-05-01), Sunshine et al.
patent: 4656177 (1987-04-01), Sunshine et al.
patent: 4749711 (1988-06-01), Sunshine et al.
patent: 4749721 (1988-06-01), Sunshine et al.
patent: 4749722 (1988-06-01), Sunshine et al.
patent: 4783465 (1988-11-01), Sunshine et al.
patent: 4839354 (1989-06-01), Sunshine et al.
patent: 4871733 (1989-10-01), Sunshine et al.
patent: 4883818 (1989-11-01), Sunshine et al.
patent: 4923898 (1990-05-01), Sunshine et al.
patent: 4962124 (1990-10-01), Sunshine et al.
patent: 4975426 (1990-12-01), Sunshine et al.
patent: 4980375 (1990-12-01), Sunshine et al.
patent: 4985459 (1991-01-01), Sunshine et al.
patent: 4990535 (1991-02-01), Cho et al.
patent: 5025019 (1991-06-01), Sunshine et al.
patent: 5075114 (1991-12-01), Roche
patent: 5100918 (1992-03-01), Sunshine et al.
patent: 5215755 (1993-06-01), Roche et al.
patent: 5286751 (1994-02-01), Sunshine et al.
patent: 5296233 (1994-03-01), Batista et al.
patent: 5373022 (1994-12-01), Fawzi et al.
patent: 5374659 (1994-12-01), Gowan, Jr.
patent: 5385941 (1995-01-01), Fawzi et al.
patent: 5674522 (1997-10-01), Shah et al.
patent: 5712310 (1998-01-01), Koch
patent: 5759579 (1998-06-01), Singh et al.
patent: 6017932 (2000-01-01), Singh et al.
patent: B1 4522899 (1992-10-01), Sunshine et al.
patent: 0856310A2 (1998-05-01), None
patent: WO 92/15332 (1992-09-01), None
patent: PCT9632941 (1996-10-01), None
patent: WO 98/38983 (1998-09-01), None
Lemsip Power +, Patient Information Leaflet, Product Literature, 1996.
Dr. S.D. Oliver, “Pharmacokinetics and Clinical Activity of a Soluble Combination of Ibuprofen and Pseudophedrine” European Journal of Clinical Researh (1996) 8:269-280.
Gelotte Cathy Klech
Hills Joanna F.
Pendley, II Charles E.
Shah Manoj N.
Jagoe Donna
Krass Frederick
Mc-Neil-PPC, Inc.
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