Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-04-05
2011-04-05
Swartz, Rodney P. (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S007200, C435S253100, C436S501000, C436S518000, C424S130100, C424S139100, C424S163100, C424S164100, C424S168100, C424S184100, C424S185100, C424S234100, C424S248100
Reexamination Certificate
active
07919258
ABSTRACT:
Methods for diagnosingMycobacterium tuberculosisinfection in a human that include providing blood serum, contacting the serum with an Eis antigen fixed on a substrate, thereby forming complexes of Eis antigen with a human antibody that binds to the Eis antigen, contacting the antibody/Eis complexes with a labeled anti-human secondary antibody, and measuring a titer of the human antibody bound to the Eis antigen. In addition, statistically significant positive or negative diagnosis of infection withMycobacterium tuberculosisis provided by comparing patient serum antibody titer with a second titer from a negative control blood sample.
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Dahl, John L. et al., “Subcellular Localization of the Intracellular Survival-Enhancing Eis Protein of Mycobacterium tuberculosis”, Infection and Immunity, Jul. 2001, p. 4295-4302, American Society for Microbiology.
Friedman Richard L.
Samuel Linoj P.
Arizona Board of Regents on Behalf of the University of Arizona
Milczarek-Desai Gavin J.
Quarles & Brady LLP
Swartz Rodney P.
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