Chemistry: molecular biology and microbiology – Apparatus – Including condition or time responsive control means
Reexamination Certificate
2011-05-10
2011-05-10
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Apparatus
Including condition or time responsive control means
C435S287200
Reexamination Certificate
active
07939312
ABSTRACT:
Methods and apparatus for effecting rapid thermocycling in connection with the polymerase chain reaction are disclosed. A sample assembly having a relatively small thermal mass is heated to desired PCR operating temperatures, and a separate cooling assembly is used to rapidly lower the temperature as required. In one embodiment, a sample assembly with an integrated heating element is isolated from a relatively large thermal mass cold sink when the temperature of a sample is to be raised or maintained, and brought in contact with the cold sink when the temperature is desired to be lowered.
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Bickmore, Jr. William D.
Hummel Jared S.
Roberts Danvern R.
DxNA LLC
Holme Roberts & Owen LLP
Horlick Kenneth R.
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