Chemistry: molecular biology and microbiology – Apparatus – Mutation or genetic engineering apparatus
Patent
1993-12-14
1996-04-02
Beisner, William H.
Chemistry: molecular biology and microbiology
Apparatus
Mutation or genetic engineering apparatus
4353031, 4353052, 935 85, C12M 140, C12M 138
Patent
active
055040071
ABSTRACT:
A thermal cycle apparatus comprises a body having a hollow interior and an access for the passage of liquid into an out of the body. Thermally conductive liquid is contained within the interior of the body. This liquid has a thermal capacity greater than the thermal capacity of the body itself. A pump or piston is provided for moving liquid into and out of the body in conjunction with the access opening. The liquid within the body is alternated between lower and higher temperatures in repeating cycles. A well or container for holding a sample of material to be subjected to cyclic thermal changes is held in contact with the liquid within the body in order to conduct the cyclic temperature changes of the liquid to the sample. A method for thermally cycling samples of material between lower and higher temperatures is also within the purview of the present invention.
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Helge Torgersen, Dieter Blaas and Tim Skern, "Low Cost Apparatus for Primer-Directed DNA Amplification Using Thermus aquaticus-DNA Polymerase", 1989. Analytical Biochem. vol. 176, pp. 33-35.
Royal A. McGraw, Eric K. Steffe and Clyde A. Hutchinson III, "Simple Programmable Apparatus for Enzymatic DNA Amplificationp", 1988. DNA and Protein Eng. Tech. vol. 1, No. (5) pp. 65-67.
Heinz Ulrich Weier and Joe W. Gray, "A Programmable System to Perform the Polymerase Chain Reaction", 1988. DNA. vol. 7. No. (6) pp. 441-447.
Becton Dickinson and Company
Beisner William H.
Thomas Nanette S.
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