Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleo

Details Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleo Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleo

1995-06-09

1998-02-24

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 424 165, 536 111, A61K 5100, A61M 3614

Patent

active

057209359

ABSTRACT:
A method of making a radiolabeled pyrimidine nucleoside or nucleotide is described. In the method, a stannylated pyrimidine nucleoside or nucleotide is contacted in an aqueous solution with a radioactive iodide, bromide, chlorine or astatine ion in the presence of an acidic hydrogen peroxide oxidizing solution comprising at least a 3:1 ratio of 30% hydrogen peroxide to 1N acid (v/v), whereby a water soluble pyrimidine nucleoside or nucleotide labeled with radioactive iodine, bromine, chlorine or astatine is formed. Kits suitable for practicing the method are also disclosed.

REFERENCES:
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patent: 4851520 (1989-07-01), Kassis et al.
patent: 5077034 (1991-12-01), Kassis et al.
patent: 5094835 (1992-03-01), Kassis et al.
patent: 5308605 (1994-05-01), Kassis et al.
patent: 5468853 (1995-11-01), Baranowski-Kortylewicz
Journal of Labelled Compounds and Radiopharmaceuticals, vol. XXXIV, No. 6, pp. 513-521 (1994).

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