Rapid self-contained assay format

Details Rapid self-contained assay format Rapid self-contained assay format

1997-10-14

1998-10-20

Ludlow, Jan

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Calorimeter

422 58, 422 61, 435 71, 435 792, 435 794, 435970, 436530, G01N 33558

Patent

active

058242686

ABSTRACT:
A test strip, a device incorporating the test strip and a method for use of the test strip within the device detecting an analyte in a solution or bodily fluid are disclosed. The test strip was three zones, a reaction zone coated with a substance that binds the analyte, a sample zone with a region for addition of the sample of solution or fluid, and a detection region zone with a region coated with detection reagent. An absorbent pad underlies the reaction zone. The reaction zone is a small membrane and is physically in contact on its upper surface with both the sample zone and the detection zone. The test strip is incorporated into a device which includes a sample collection/transferring device, a housing for holding the test strip, and a container for holding solvent solutions at both outer ends of the test strip such that the solvent solutions can come into contact with the outer ends of the test strip when pressure is applied to the ends. The method involves placing a sample onto the strip using the sample collection/transferring device, causing solvent solutions to come into contact with the sample and detection membranes, and observing the test results. The resulting orthogonal buffer flow is an improvement over current methods because it reduces the number of steps and the time required for performance of a sequential assay.

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