Rapid resolution process of clopidogrel base and a process...

Details Rapid resolution process of clopidogrel base and a process... Rapid resolution process of clopidogrel base and a process...

2005-06-10

2008-11-04

Morris, Patricia L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07446200

ABSTRACT:
The present invention discloses a rapid resolution process of racemic clopidogrel base followed by conversion of the resolved (S) isomer to crystalline Clopidogrel bisulfate Form I. The invention also discloses novel racemization process of the unwanted (R) isomer of clopidogrel base. The invention further discloses an improved process for preparation of acid addition salts of clopidogrel.

REFERENCES:
patent: 4847265 (1989-07-01), Badorc et al.
patent: 6429210 (2002-08-01), Bousquet et al.
patent: 6737411 (2004-05-01), Valeriano et al.
patent: 6800759 (2004-10-01), Valeriano et al.
patent: WO04/74215 (2004-09-01), None
patent: 104663 (2005-11-01), None

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