Rapid, quantitative peptide synthesis using mixed anhydrides

Details Rapid, quantitative peptide synthesis using mixed anhydrides Rapid, quantitative peptide synthesis using mixed anhydrides

1981-03-10

1982-09-28

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

043517625

ABSTRACT:
In the synthesis of a polypeptide chain wherein an N.sup..alpha. -urethane-protected amino acid mixed anhydride is coupled with an amino-unprotected second amino acid, the improvement comprising conducting said coupling at room temperature or above. This method provides rapid, essentially quantitative reactions without the necessity for reduced temperatures. The method is particularly useful in the solid-phase synthesis of peptides where shortened coupling cycles and improved yields of substantially pure products are obtained.

REFERENCES:
patent: 2713045 (1955-07-01), Wieland et al.
patent: 2713574 (1955-07-01), Vaughan, Jr.
patent: 2715119 (1955-08-01), Wieland et al.
patent: 4267344 (1981-05-01), Halstrom et al.

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