Rapid method for interrupting or attenuating poly-drug dependenc

Details Rapid method for interrupting or attenuating poly-drug dependenc Rapid method for interrupting or attenuating poly-drug dependenc

1990-05-31

1992-10-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424451, 424463, 424464, 514214, 514810, 514811, 514812, 514813, A01N 4346, A61K 3155, A61K 908, A61K 948

Patent

active

051529947

ABSTRACT:
The administration to a poly-drug addict of ibogaine, ibogaine, tabernanthine, alkaloids in the family of apocynaceae, or their non-toxic salts have been discovered to interrupt the physiological and psychological aspects of poly-drug dependency (heroin, cocaine, alcohol, nicotine, caffeine, amphetamine, desoxyephedrine or methadone in combinations thereof). A single treatment or series of treatments may be effective for one to eighteen months or longer. Treatment consists of the oral or rectal administration of ibogaine, ibogamine, tabernanthine or their salts or derivatives in dosage ranges of 1 mg/kg to 60 mg/kg.

REFERENCES:
patent: 4499096 (1985-02-01), Lotsoff
patent: 4587243 (1986-05-01), Lotsoff
patent: 4857523 (1989-08-01), Lotsoff
"Effect of ibogaine on naloxone-precipitated withdrawal syndrome in chronic morphine-dependent rats", Dzoljic et al, Arch. Int. Pharmacodyn Ther., 294, 64-70, 1988.

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