Rapid, large scale, automatable high pressure peptide synthesis

Details Rapid, large scale, automatable high pressure peptide synthesis Rapid, large scale, automatable high pressure peptide synthesis

1978-11-20

1980-03-11

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125TR, 2601125S, 2601125T, 2601125LH, C07C10352

Patent

active

041927982

ABSTRACT:
In the method for the synthesis of a polypeptide chain on an insoluble solid support wherein an amino acid is introduced into a reactor packed with an insoluble solid support containing substituent groups reactive with said amino acid, coupling said amino acid to said support by condensation reaction with said reactive substituent groups, introducing a second similar or dissimilar amino acid into said reactor and coupling said second amino acid to said first amino acid and repeating the process until the desired polypeptide is obtained, the improvement wherein a high pressure flow system is used and the reaction pressure in said reactor during said synthesis is at least 200 psi up to 10,000 psi or more, in order to obtain rapid reactions and quantitative yields of the desired products.

REFERENCES:
patent: 3531258 (1970-09-01), Merrifield et al.
patent: 3557077 (1971-01-01), Brunfeldt et al.
patent: 3715190 (1973-02-01), Park et al.
patent: 4062815 (1977-12-01), Hughes et al.

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