Rapid isolation of osteoinductive protein mixtures from...

Details Rapid isolation of osteoinductive protein mixtures from... Rapid isolation of osteoinductive protein mixtures from...

2006-10-27

2009-11-24

Afremova, Vera (Department: 1657)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins from mammals or birds

Bones; tendons; teeth; cartilage

C530S412000, C514S021800, C424S549000

Reexamination Certificate

active

07622562

ABSTRACT:
A method for purifying bone-derived osteoinductive proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight ultrafiltration process, and a recovery process. The high and low ultrafiltration processes preferably select proteins having a nominal molecular weight between approximately 8 kilodaltons and approximately 100 kilodaltons. Processes of the present invention may be used to recover osteoinductive proteins from bone demineralization waste streams.

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