Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2011-08-02
2011-08-02
Kim, Young J (Department: 1637)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S006120, C435S091100
Reexamination Certificate
active
07989185
ABSTRACT:
A rapid diagnostic assay for influenza virus, particularly avian influenza and more particularly H5N1, is described. The assay is based on amplification of a significant portion of the hemagglutinin (HA) gene and sequencing of several loci within the HA gene, using techniques which can obtain real time sequence information from multiple sites of a target DNA, in particular pyrosequencing and bioluminescence regenerative cycle. The assay contemplates the use of information-rich subsequences within the HA gene, e.g., (1) a glycosylation sequon; (2) receptor binding site; and (3) HA1/HA2 cleavage site. Other subsequences for sequencing include strain and clade markers, which vary among H5N1 strains.
REFERENCES:
patent: 4971903 (1990-11-01), Hyman
patent: 6015664 (2000-01-01), Henrickson et al.
patent: 6210891 (2001-04-01), Nyren et al.
patent: 6258568 (2001-07-01), Nyren
patent: 6274320 (2001-08-01), Rothberg et al.
patent: 6841128 (2005-01-01), Kambara et al.
patent: 7141370 (2006-11-01), Hassibi et al.
patent: 2003/0082583 (2003-05-01), Hassibi et al.
Subbarao et al., “Characterization of an Avian Influenza A (H5N1) Virus Isolates from a Child with a Fetal Respiratory Illness,” Science, Jan. 1998, vol. 279, pp. 393-396.
Yuen et al., “Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus.” The Lancet, Feb. 1998, vol. 351, pp. 467-471.
Gharizadeh et al., “Methodological improvements of pyrosequencing technology,” Journal of Biotechnology, 2006, vol. 124, pp. 504-511.
Jipling Li, et al., “Typing and Subtyping Influenza Virus Using DNA Microarrays and Multiplex Reverse Transcriptase PCR,” Journal of Clinical Microbiology, Feb. 2001, vol. 39, No. 2, 696-704.
Ya Ha, et al., “H5 avian and H9 swine influenza virus hemagglutinin structures: possible origin of influenza subtypes,” EMBO Journal, 2002, vol. 21, No. 5, 865-875.
Erich Hoffmann, et al., “Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines,” PNAS, Sep. 6, 2005, vol. 102, No. 36, 12915-12920.
Baback Gharizadeh, et al., “Methodological improvements of pyrosequencing technology,” Journal of Biotechnology, 2006, 4207, 1-8.
Davis Ronald W.
Diamond Lisa
Kumm Jochen
Pourmand Nader
Aston David J.
Kim Young J
Peters Verny LLP
The Board of Trustees of the Leland Stanford Junior University
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