Rapid inducible beta-lactamase screen test

Details Rapid inducible beta-lactamase screen test Rapid inducible beta-lactamase screen test

1996-07-26

2000-03-28

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 26, 435 29, 435 4, 435975, C12Q 118, C12Q 132, C12Q 102, C12Q 100

Patent

active

060430486

ABSTRACT:
In an assay for determination of beta-lactam antibiotic resistance in a target bacterial strain, the strain is grown in the presence of both a beta-lactamese inducing antibiotic and a beta-lactam indicator antibiotic [which kills or inhibits the growth of bacteria] unable to hydrolyze beta-lactam antibiotics. Growth, indicative of drug resistance in the target strain, is monitored by detecting a fluorophor released by the enzymatic cleavage of a metabolizable fluorogenic compound.

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Sanders, et al.; Euro. J. Clin. Microbiol.; Clinical Importance of Inducible Beta-Lactamases in Gram-Negative Bacteria; vol. 6, No. 4; pp. 425-437; Aug. 87.
Jorgensen, J.H.; Chemioterapia; Susceptibility Test Methods Which May Be Able to Predict the Emergence of Resistance to Newer .beta.-Lactam Antibiotics; vol. 4, No. 1; pp. 7-13; Feb. 85.

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