Rapid genetic screening method

Details Rapid genetic screening method Rapid genetic screening method

1997-03-21

2000-02-01

Marschel, Ardin H.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 221, 204451, C12Q 168, C07H 1900

Patent

active

060201266

ABSTRACT:
A rapid and sensitive detection method capable of reliably distinguishing fragments identical to a defined sequence from fragments containing a single base pair mismatch relative to the defined sequence. The method employs a peptide analog antisense probe, such as a peptide nucleic acid (PNA) probe, which hybridizes with DNA to forms complexes having higher thermal stability, but greater sensitivity to base pair mismatches, than corresponding DNA/DNA complexes. The method may be used in a number of applications, including genetic screening and hybridization sequencing applications.

REFERENCES:
patent: 5593559 (1997-01-01), Wiktorowicz
Yonseong et al. "Separation of nucleic acids by capillary electrophoresis in cellulose solutions with mono- and bis-intercalating dyes" Anal. Chem., vol. 66, pp. 1168-1174, 1994.

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