Rapid generation of stable mammalian cell lines producing high l

Details Rapid generation of stable mammalian cell lines producing high l Rapid generation of stable mammalian cell lines producing high l

1998-10-20

2000-10-24

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 435 911, 435 914, 435325, 435352, 435358, 536 231, 536 241, C12N 1500, A61K 4800, C12Q 168

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active

06136536&

ABSTRACT:
Disclosed are methods, DNA sequences, vectors and cell lines useful for the rapid generation of stable mammalian cell lines expressing high levels of recombinant proteins.

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Langer et al., Virology 221 : 172-179, Jul. 1995.
M. Gossen and Hermann Bujard, "Tight control of gene expression in mammalian cells by tetracycline-responsive promoters," Proc. Natl. Acad. Sci., vol. 89, pp. 5547-5551, Jun. 1992.
S.K. Jang et al.,"Initiation of Protein Synthesis by Internal Entry of Ribosomes into the 5'Nontranslated Region of Encephalomyocarditis Virus RNA in Vivo," J. Virol,, vol. 63, No. 4, pp. 1651-1660, 1989.
Hofmann et al., "Rapid Retroviral Delivery of Tetracycline-Inducible Genes in a Single Autoregulatory Cassette," Proc. Natl. Acad. Sci. USA, 93(11): 5185-5190 (1996).

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