Rapid dissolving, uniform drug compositions and their preparatio

Details Rapid dissolving, uniform drug compositions and their preparatio Rapid dissolving, uniform drug compositions and their preparatio

1984-03-06

1985-05-14

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514781, 514869, 514960, 514761, 514951, 514259, A61K 3306, A61K 4508

Patent

active

045171793

ABSTRACT:
Rapid dissolving uniform compositions of low water solubility drugs are formed from a dry mixture of the drug having a reduced particle size in combination with properly selected and sized excipients including microcrystalline cellulose, dibasic calcium phosphate, starches and a lubricant.

REFERENCES:
patent: 3134719 (1964-05-01), Sheth et al.
patent: 3360518 (1967-12-01), Shetty
patent: 3745216 (1973-07-01), Jen et al.
Stauffer "DI-TAB" (1981), 18 pp., (Unmilled Dicalcium Phosphate in Direct Compression Tableting).
Burger, "Dissolution and Polymorphism of Metolazone", Drug Research 25:24-27 (1975).
Chiou et al., "Pharmaceutical Applications of Solid Dispersion Systems", Pharm. Sci. 60:1281-1302 (1971).
Lachman et al., "The Theory and Practice of Industrial Pharmacy", 2nd Ed., Lea & Febiger, pp. 328-337 (1976).
Navnit et al., "Influence of Dispersion Method on Dissolution Rate and Bioavailability of Digoxin from Triturations & Compressed Tablets II", Pharm. Sci. 63:3, 339-344 (1974).
Remington's Pharmaceutical Sciences, 15th Ed., Mack Publishng Company (1975).
Samyn et al., "Experiments in Powder Blending and Unblending", Pharm. Sci. 64:370-375 (1974).
Yamamoto et al., "Dissolution Behavior and Bioavailability of Phenyltoin from a Ground Mixture with Microcrystalline Cellulose", Pharm. Sci. 1484-1488.

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