Rapid differentiation of fungi from bacteria using polyene antib

Details Rapid differentiation of fungi from bacteria using polyene antib Rapid differentiation of fungi from bacteria using polyene antib

1986-09-24

1989-12-19

Benson, Robert

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 29, 435 31, 435 38, 435 39, 435805, 435810, C12Q 104

Patent

active

048882879

ABSTRACT:
Rapid differentiation between viable fungi (for example, yeast) and viable bacteria is accomplished with certain polyene antibiotics which are used in combination with a compound which is normally reducible by both the fungi and the bacteria. The antibiotics selectively and substantially inhibit the reduction of the reducible compound by the fungi but do not affect the reducing capacity of the bacteria. The particular antibiotics useful are polyenes which selectively affect the function of the cytoplasmic membrane of fungi.

REFERENCES:
patent: 3870600 (1975-03-01), Youssef
patent: 4140580 (1979-02-01), Gibson et al.
patent: 4525453 (1985-06-01), Guardino et al.
patent: 4746607 (1988-05-01), Mura et al.
Fingold et al., "Bailey and Scott's Diagnostic Microbiology" C. V. Mosby Co., St. Louis 1978, p. 21.
Garrod et al., "Antibiotic and Chemotherapy" Churchill Livingstone, Edinburgh and London, 1973, pp. 228-232.

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