Rapid differentiation of bacteria using cyclic polypeptide antib

Details Rapid differentiation of bacteria using cyclic polypeptide antib Rapid differentiation of bacteria using cyclic polypeptide antib

1986-09-24

1990-03-27

Benson, Robert

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 29, 435 39, 435 40, 435805, 435810, 435873, C12Q 104

Patent

active

049120360

ABSTRACT:
Rapid differentiation between viable gram-positive and gram-negative bacteria is accomplished with certain polypeptide antibiotics which are used in combination with a compound which is normally reducible by the bacteria. The antibiotics selectively inhibit the reduction of the reducible compound by gram-positive bacteria but do not substantially affect the reducing capacity of the gram-negative bacteria. The particular antibiotics useful are cyclic polypeptides which affect the function of the cytoplasmic membrane of bacteria. A particular polypeptide antibiotic, polymixin B, will distinguish Proteus bacteria from other gram-negative genera.

REFERENCES:
patent: 4525453 (1985-06-01), Guardino et al.
patent: 4746607 (1988-05-01), Mura et al.
Finegold et al, "Bailey and Scott's Diagnostic Microbiology" C. V. Mosby Co., St. Louis 1978, p. 21.
Garrod et al, "Antibiotic and Chemotherapy" Churchill Livingston, Edinburgh and London, 1973, pp 182-187.

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