Rapid determination of protein global folds

Details Rapid determination of protein global folds Rapid determination of protein global folds

2005-04-19

2005-04-19

Borin, Michael (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C702S027000, 36, 36

Reexamination Certificate

active

06882939

ABSTRACT:
This invention provides a method for rapidly obtaining accurate three-dimensional structure of proteins including large or multi-sub unit proteins, using a combination of NMR analysis of backbone only13C,15N or13C and15N isotopically labeled proteins which are optionally also2H isotopically labeled in the Cα position protons and residual dipolar coupling measurements in more than one partially aligned state and/or orientation data pertaining to overlapping successive peptide pairs.

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