Rapid detection of isoniazid resistance in mycobacterium tubercu

Details Rapid detection of isoniazid resistance in mycobacterium tubercu Rapid detection of isoniazid resistance in mycobacterium tubercu

1992-08-14

1997-05-27

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435810, 436501, 436 63, 536 221, 536 231, 536 2431, 536 2432, 536 2433, 935 77, 935 78, C12Q 168, C07H 2104

Patent

active

056331312

ABSTRACT:
Multi-drug resistant strains of Mycobacterium tuberculosis represent a considerable threat to public health worldwide. Resistance to isoniazid (INH), a key component of anti-tuberculosis regimens, is often associated with loss of catalase activity and virulence. The katG gene, encoding HPI catalase-peroxidase, mediates INH-sensitivity and that the high level resistance encountered clinically may be due to deletions, insertions or point mutations which reduce or eliminate the expression of the catalase gene in the chromosomal region encompassing katG. INH-resistant strains of Mycobacterium tuberculosis are detected by nucleic acid hybridization with a unique nucleic acid sequence or by amplification techniques.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
Zhang et al. (1992) Nature, vol. 358, pp. 591-593.

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