Rapid detection and drug sensitivity of malaria

Details Rapid detection and drug sensitivity of malaria Rapid detection and drug sensitivity of malaria

1996-12-20

1998-10-27

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 4, 435975, 435970, 435260, 4352582, 4352581, 422 50, 422 55, 422 61, C12Q 104, C12Q 100, C12N 104, G01N 3353

Patent

active

058276815

ABSTRACT:
A test kit for the rapid detection and drug sensitivity of malaria is presented. The test kit of the present invention comprises a unique microscope/slide incubation chamber which permits rapid detection of malaria in wet blood samples using a regular transmitted light microscope to detect opaque hemozoin particles.

REFERENCES:
F. Markwardt, "Inventory of Coagulation Inhibitors from Animals Feeding on Blood" 1994 Stuttgart, Thrombosis and Haemostasis 72(3)477-80.
B. Kotecka, K.H. Rieckmann, "An inexpensive and simple method for screening antimalarial drugs" 1992 Stuttgart, Trop.Med.Parasitol.43(1992)9-12.
G. Jamjoon, "Formation and Role of Malaria Pigment" 1988, Review of Infectious Diseases vol. 10, No. 5, pp. 1029-1034 University of Chicago.
G. Jamjoon, "Patterns of Pigment Accumulation in Plasmodium falciparum trophozites in Peripheral Blood Samples" 1988 Am.J.Trop.Med.Hyg. 39(1)pp. 21-25 American Society of TropicalMedicine and Hygiene.
C.Lawrence and J. Olson, "Birefringent Hemozoin Identifies Malaria" 1985 Brief Scientific Reports vol. 86, No. 3, pp. 360-363.
G. Jamjoon, "Dark Field Microscopy for Detection of Malaria in Unstained Blood Films" 1983 J. of Clin. Microbiol. vol 17, No. 5, pp. 717-721.
K. Rieckmann, "Visual In-vitro Test for Determining the Drug Sensitivity of Plasmodium falciparum" The Lancet, Jun. 12, 1982, pp. 1333-1335.
K. Rieckmann et al., "Drug Sensitivity of Plasmodium falciparum" The Lancet, Jan. 7, 1978, pp. 22-23.

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