Chemistry: molecular biology and microbiology – Apparatus – Means for separation or recovery of a microorganism from...
Reexamination Certificate
2005-07-05
2005-07-05
Beisner, William H. (Department: 1744)
Chemistry: molecular biology and microbiology
Apparatus
Means for separation or recovery of a microorganism from...
C435S297200, C435S307100, C422S105000
Reexamination Certificate
active
06913921
ABSTRACT:
A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes cell loss, and automatically positions cell samples at the position in which a microtome blade will section them. The apparatus includes a cell flow pathway defined by an inflow tube for delivering cell fragments from a cell sample to a sample port. The sample port is in fluid communication with a tissue cassette having attached thereto a filter. The cell flow pathway is in communication with a reagent flow pathway for delivering the reagents through the sample port to the cassette. The apparatus is configured such that the application of pressure directs the cell fragments from the cell sample through the cell flow pathway, and effects delivery of the reagents through the reagent flow pathway. The apparatus produces an embedded cell block having concentrated cells near the plane of the block to be sectioned in a quick and efficient manner.
REFERENCES:
patent: 2923669 (1960-02-01), Poitra
patent: 3227130 (1966-01-01), Weiskopf
patent: 4557903 (1985-12-01), McCormick
patent: 4569647 (1986-02-01), McCormick
patent: 4604964 (1986-08-01), Gordon et al.
patent: 4656047 (1987-04-01), Kok et al.
patent: 5080869 (1992-01-01), McCormick
patent: 5137710 (1992-08-01), Smalley et al.
patent: 5269671 (1993-12-01), McCormick
patent: 5354370 (1994-10-01), Schmehl
patent: 5665398 (1997-09-01), McCormick
patent: 5691633 (1997-11-01), Liu et al.
patent: 5817032 (1998-10-01), Williamson, IV et al.
patent: 5928934 (1999-07-01), McCormick
patent: 6207408 (2001-03-01), Essenfeld et al.
patent: 6395234 (2002-05-01), Hunnell et al.
patent: 6413767 (2002-07-01), Izvoztchikov et al.
patent: 2928790 (1981-02-01), None
patent: 2000146782 (2000-05-01), None
Diaz-Rosario, Luis A. et al, “Cell Block Preparation by Inverted Filter Sedimentation is Useful in the Differential Diagnosis of Atypical Glandular Cells of Undetermined Significance in ThinPrep Specimens,”Cancer, 90(5): 265-272 (2000).
Fahey, Colleen et al, “Collodion Bag: A Cell Enhanced Cell Collection,”Laboratory Medicine, 74(2): 94-96 (1993).
Srinivasan, Mythily et al, “Effect of Fixatives and Tissue Processing on the Content and Integrity of Nucleic Acids,”American Journal of Pathology, 161(6): 1961-1971 (2002).
Yang, Grace C.H. et al., “Use for Body Fluids, Fine Needle Aspirations and Endometrial Brush Biopsies,”Acta Cytologica, 42(3): 703-706 (1998).
Beisner William H.
Nutter & McClennen & Fish LLP
University of Massachusetts
LandOfFree
Rapid cell block embedding method and apparatus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Rapid cell block embedding method and apparatus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rapid cell block embedding method and apparatus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3384577