Rapid assay of activators and inhibitors of clotting

Details Rapid assay of activators and inhibitors of clotting Rapid assay of activators and inhibitors of clotting

1994-12-29

1996-10-22

Spiegel, Carol A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435 4, 435 23, 435 24, 435968, 436536, 436546, 436 69, 436800, C12Q 156

Patent

active

055675964

ABSTRACT:
Assays and reagents are provided for the measurement of components that are involved in either enzyme-catalyzed degradation of a substrate, such as in fibrinogenolysis or fibrinolysis; or enzyme-catalyzed polymerization of a substrate, such as in fibrinogen polymerization into fibrin. The method involves using a fluorescent-labeled substrate in an enzyme-catalyzed reaction, and measurement of the component's effects on the fluorescence emission of the enzyme-catalyzed reaction such as quenching or dequenching, as a measure of the component's activity.

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F. S. Stevens, "Polymeric Collagen Fibrils: An Example of Substrate-Mediated Steric Obstruction of Enzymic Digestion, " Biochimica et Biophysica Acta, 452 (1976): 151-160.
D. Smith et al., "A Sensitive and Specefic Assay for Plasminogen Activators, " Thrombosis Research, 37(1985): 533-541.

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