Rapid acting intravenous emulsions of omega-3 fatty acid esters

Details Rapid acting intravenous emulsions of omega-3 fatty acid esters Rapid acting intravenous emulsions of omega-3 fatty acid esters

1985-10-15

1987-07-07

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514 77, 514 78, 514822, A61K 3120, A61K 31685

Patent

active

046788085

ABSTRACT:
Described are lipid emulsions of marine oils comprising high concentrations of omega-3-fatty acid esters and low concentrations of free fatty acids for intraveneous administration for the treatment of thrombic disease states. More specifically, a lipid emulsion for parenternal use is provided comprising an emulsifier, water and a marine oil comprising an omega-3-fatty ester in which the concentration of the free fatty acid in the emulsion is below about 5 meq/l.

REFERENCES:
patent: 4513008 (1985-04-01), Revici et al.
Needleman, P. et al., "Triene Prostaglandins" Proc. Natl. Acad. Sci. 76(2): 944-948, 1978.
Bang, H. et al., "The Composition of Food Consumed by Greenland Eskimos" Acta Med Scand. 200:69-73, 1976.
Sanders, T. et al., "A Comparison of the Influence on Plasma Lipids on & Platelet . . . " Bnt. J. Nut. 50:521,522, 1983.
Goodnight, S. et al., "The Effects of Dietary .omega.3 Fatty Acids . . . " Blood, 58(5): 880-885, 1981.
Thorngren, M. et al., "Effects of 11-Week Increase in Dietary Eicosapentaenoic Acid" The Lancet Nov. 1981, 1190.
Lorenz, R. et al., "Platelet Function . . . " Circulation 67(3):504-511, 1983.

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