Rapamycin polymorphs and uses thereof

Details Rapamycin polymorphs and uses thereof Rapamycin polymorphs and uses thereof

2007-10-16

2007-10-16

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C540S456000

Reexamination Certificate

active

11206472

ABSTRACT:
The present invention provides rapamycin polymorph Form II. This invention also provides processes for preparing rapamycin polymorph Form II and pharmaceutical compositions including rapamycin polymorph Form II.

REFERENCES:
patent: 3929992 (1975-12-01), Sehgal et al.
patent: 3993749 (1976-11-01), Sehgal et al.
patent: 0652219 (1995-05-01), None
Vézina et al., “Rapamycin (AY-22,989), A New Antifungal Antibiotic, I. Toxonomy of the Producing Streptomycete and Isolation of the Active Principle”, J. Antibiot., 28, 721 (Oct. 1975).
Sehgal et al., “Rapamycin (AY-22,989), A New Antifungal Antibiotic, II. Fermentation, Isolation and Characterization”, J. Antibiot. 28, 727 (Oct. 1975).
Baker et al., “Rapamycin (AY-22,989), A New Antifungal Antibiotic, III. In Vitro and In Vivo Evaluation”, J. Antibiot. 31, 539 (Jun. 1978).
Swindells et al., “The X-ray Crystal Structure of Rapamycin, C53H79NO13”Can. J. Chem., 56: 2491 (1978).

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