Rapamycin esters

Details Rapamycin esters Rapamycin esters

1991-10-17

1993-06-22

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540455, C07D48706, A61K 3133

Patent

active

052216705

ABSTRACT:
A compound of the structure ##STR1## where R.sup.1, R.sup.2, and R.sup.3 are each, independently, hydrogen or ##STR2## with the proviso that R.sup.1, R.sup.2, and R.sup.3 are not all hydrogen; R.sup.4 is --(CH.sub.2).sub.m X(CH.sub.2).sub.n CO.sub.2 R.sup.5 or ##STR3## R.sup.5 and R.sup.6 are each, independently, alkyl, aralkyl, or phenyl which is optionally mono-, di-, or tri-substituted with a substituent selected from alkyl, alkoxy, hydroxy, cyano, halo, nitro, carbalkoxy, trifluoromethyl, amino, or a carboxylic acid;

REFERENCES:
patent: 3929992 (1975-12-01), Sehgal et al.
patent: 3993749 (1976-11-01), Sehgal et al.
patent: 4316885 (1982-02-01), Rakhit
patent: 4401653 (1983-04-01), Eng
patent: 4650803 (1987-03-01), Stella et al.
patent: 4885171 (1989-12-01), Surendra et al.
patent: 5078999 (1992-01-01), Warner
patent: 5080899 (1992-01-01), Sturm et al.
patent: 5091389 (1992-02-01), Ondeyka et al.
patent: 5100883 (1992-03-01), Schiehser
patent: 5100899 (1992-03-01), Calne
Rosen et al "Dictionary of Immunology" pp. 18,88 Mar. 1991.
Huffer et al "Introduction to Human Immunology" p. 161, Jan. 1987.
J. Antibiot. 28, 721-726 (1975).
J. Antibiot. 28, 727-732 (1975).
J. Antibiot. 31, 539-545 (1978).
Can. J. Physiol. Pharmacol. 55, 48 (1977).
FASEB 3, 3411 (1989).
FASEB 3, 5256 (1989).
Lancet, 1183, (1978).
Immunology, C. V. Moseby Co., pp. 12.8-12.11 (1989).

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