Rapamycin carbohydrate derivatives

Details Rapamycin carbohydrate derivatives Rapamycin carbohydrate derivatives

2007-01-09

2007-01-09

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S006500, C536S007100, C536S018100, C540S456000, C514S291000, C424S422000, C623S001110, C623S001230

Reexamination Certificate

active

10845747

ABSTRACT:
This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin carbohydrate derivatives having enhanced pharmacokinetic and/or pharmacodynamic profiles. For example, administration of the rapamycin carbohydrate derivative results in altered pharmacokinetic profiles and reduced toxicities. Thus, the present invention provides compounds with characteristics that are distinct from other drugs in its class such as rapamycin.

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