Rapamycin analogs as immunosuppressants and antifungals

Details Rapamycin analogs as immunosuppressants and antifungals Rapamycin analogs as immunosuppressants and antifungals

1991-08-07

1992-08-11

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D49106

Patent

active

051380510

ABSTRACT:
Reduction of C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosuppressant, antifungal, and antiinflammatory activities.

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